Abstract
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, translational and clinical research related to cancer cell biology, genomics, precision medicine, oncology internal medicine, radiotherapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Highlights
Angiogenesis, characterized by the formation of new vessels from preexisting blood vessels, participates in the progression of many malignant tumors by supplying oxygen and nutrients[1]
HF inhibited the levels of secreted proMMP-2, proMMP-9, and vascular endothelial growth factors (VEGFs)-A without altering transcripts
Our results suggest that HF, through its proapoptotic and potential antiangiogenic properties on primary acute myeloid leukemia (AML) cells, might be a useful experimental agent, in combination with existing drugs, for new therapeutic approaches in the treatment of this incurable disease
Summary
Angiogenesis, characterized by the formation of new vessels from preexisting blood vessels, participates in the progression of many malignant tumors by supplying oxygen and nutrients[1]. By binding to VEGF receptors at the surface of ECs, VEGF activates cell signaling pathways involved in the activation of the proliferation and survival of ECs[1,2,7]. In addition to VEGF, matrix metalloproteinases (MMPs) are regulators of pathologic angiogenesis[8,9,10]. The proteolytic activities of MMP-2 and MMP-9 are implicated in tumor-associated processes such as cell growth, survival, migration, invasion, and angiogenesis[8,12,13]. By binding cell surface proteins, the proforms of MMP-2 and MMP-9 can directly trigger intracellular signaling pathways involved in the modulation of cell growth and survival, migration, or angiogenesis[8,14]
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