Abstract
Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathic pain. In a rat model of neuropathic pain induced by spared nerve injury, mechanical allodynia, as a behavioural sign of neuropathic pain, was assessed by measuring 50% paw withdrawal threshold with von Frey filaments. Activities of dorsal horn wide dynamic range (WDR) neurons were examined by extracellular electrophysiological recording in vivo. Spinal administration of PGB exerted a significant antiallodynic effect and a prominent inhibitory effect on the hypersensitivity of dorsal horn WDR neurons in rats with spared nerve injury. The antiallodynic action of PGB is likely dependent on the suppression of WDR neuron hyperexcitability in rats with neuropathic pain.
Highlights
Pregabalin (PGB) is a novel antiepileptic drug and is used as a first-line medication for the treatment of neuropathic pain
In the present study, we found that spinal administration of PGB had a significant antiallodynic effect in a rat model of neuropathic pain induced by SNI, which was associated with a marked inhibitory effect on the hypersensitivity of dorsal horn wide dynamic range (WDR) neurons in SNI rats
Consistent with previous reports that PGB had a potent analgesic activity in rodent models of neuropathic pain [7,14,23], the present study provides evidence showing that intrathecal administration of PGB has a significant reversal effect on the reduction of ipsilateral paw withdrawal threshold (PWT) in response to von Frey filaments in SNI rats, confirming the antiallodynic effect of PGB on neuropathic pain
Summary
Pregabalin (PGB) is a novel antiepileptic drug and is used as a first-line medication for the treatment of neuropathic pain. Objectives: To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathic pain. Methods: In a rat model of neuropathic pain induced by spared nerve injury, mechanical allodynia, as a behavioural sign of neuropathic pain, was assessed by measuring 50% paw withdrawal threshold with von Frey filaments. Activities of dorsal horn wide dynamic range (WDR) neurons were examined by extracellular electrophysiological recording in vivo. Results: Spinal administration of PGB exerted a significant antiallodynic effect and a prominent inhibitory effect on the hypersensitivity of dorsal horn WDR neurons in rats with spared nerve injury. Conclusion: The antiallodynic action of PGB is likely dependent on the suppression of WDR neuron hyperexcitability in rats with neuropathic pain
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