Abstract
Depression is one of the world's most serious public health issues. What is worse, the number of people suffering from depression is expanding and shows a younger-age trend. The primary treatment for depression is drug therapy. Selective serotonin reuptake inhibitors (SSRIs), as the second generation of novel antidepressants, are highly recognized antidepressant medicines that are widely utilized in clinical practice and have become first-line drugs for the treatment of depression. This article provides a thorough and detailed introduction to SSRIs. It focuses mostly on the etiology of depression, the specific mechanism of SSRIs, the specific application of SSRIs, and properties of distinct SSRI drugs. This article looks at the superiority and significance of SSRI medicines in the treatment of depression. At the same time, the limitations and shortcomings of SSRI drugs were discussed, and the future development of SSRI drugs was envisaged.
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