The anesthetic efficacy of sevoflurane versus that of isoflurane in surgical repair of cleft lips and cleft palates in infants and young children

Abstract

Objective To compare the anesthetic efficacy of sevoflurane with that of isoflurane in surgical repair of cleft lips and cleft palates in infants and young children.Methods 100 ASA Ⅰ-Ⅱ infants and young children undergoing surgical repair were randomly assigned to receive sevoflurane ( 50 patients,sevoflurane group ) or isoflurane ( 50 patients,isoflurane group ) for maintaining general anesthesia.Time to awakening from medication termination,time to extubation,time to full consciousness,and incidence rate of complications were observed; Fa/Fi and levels of creatinine and urea nitrogen 24 h after surgery were noted.Results Time to awakening,time to extubation,and time to full consciousness was significantly shorter in sevoflurane group than in isoflurane group ( P＜ 0.05 ）, the incidence rate of complications was significantly lower in sevoflurane group than in isoflurane group ( P＜ 0.05 ).Fa/Fi within 20 min was significantly greater in sevoflurane group than in isoflurane group ( P＜ 0.05 ) ; levels of creatinine and urea nitrogen did not differ significantly between these 2 groups 24 h after surgery ( P ＞ 0.05 ).Conclusions Sevoflurane is safer and has a better anesthetic efficacy in surgical repair of cleft lips and cleft palates in infants and young children. Key words: Cleft lips; Sevoflurane; Isoflurane; Infants and young children