The analgesic efficacy of ketamine for septorhinoplasty: a meta-analysis study.

Abstract

The analgesic efficacy of ketamine supplementation was not well-established for septorhinoplasty and this meta-analysis aimed to compare ketamine supplementation with placebo for the postoperative pain control of septorhinoplasty. We systematically searched several databases, including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and included randomized controlled trials (RCTs) regarding the effect of ketamine supplementation versus placebo for pain control after septorhinoplasty. This meta-analysis was conducted by random effect model. Five RCTs were included in this meta-analysis. In comparison with control group for septorhinoplasty, ketamine supplementation was associated with significantly decreased pain scores at 30min (SMD = -3.84; 95% CI = -6.73 to -0.96; P = 0.009), pain scores at 1h (SMD = -2.70; 95% CI = -3.79 to -1.61; P < 0.00001), pain scores at 2h (SMD = -1.83; 95% CI = -3.01 to -0.64; P = 0.003), rescue analgesics (OR = 0.08; 95% CI = 0.04 to 0.17; P < 0.00001), but unraveled no obvious impact on pain scores at 4h (SMD = -1.13; 95% CI = -3.37 to 1.12; P = 0.32) or the incidence of nausea and vomiting (OR = 0.71; 95% CI = 0.30 to 1.72; P = 0.45). Ketamine supplementation was effective to improve pain relief after septorhinoplasty.