Abstract
Objective To explore the behavioral and related amygdalar temporal response to emotional pictures in individuals with panic disorder(PD). Methods Functional magnetic resonance imaging (fMRI) was adopted to examine the neural substrates of emotional pictures processing in 13 first-episode unmedicated PD subjects (PD) and 13 healthy controls. Analyses focused on the temporal dynamics of the blood-oxygen level dependant (BOLD) signal change in the amygdala across blocks of positive, neutral and negative emotional pictures in PD versus healthy controls. The valence score was also recorded to emotional pictures. Results (1) For positive pictures task, left amygdale showed “Group×Time” interaction effect ［F (4, 96)=4.89, P 0.05）. Conclusions The augmented and sensitive amygdalar responses to positive and negative IAPS pictures in patients with PD compared with the healthy controls participants support the hypothesis of sensitive and augmented response in panic disorder. Key words: Panic disorder; Magnetic resonance imaging; Amygdala; Habituation，psychophysiologic; International affective picture system
Published Version
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