Abstract
Alcohol, in an average dose of 58 mg per kilogram per minute, was infused during 20 minutes into 10 anesthetized dogs. Cardiac output and the external work of the heart decreased, with no change in arterial blood pressure. Coronary sinus outflow increased as a result of a fall in coronary vascular resistance. There was no change in either coronary arteriovenous oxygen difference or myocardial oxygen extraction. Oxygen consumption, however, increased in the myocardium. The results are discussed in terms of the effect of alcohol on the pain of angina pectoris.
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