The Activation of DNA Damage Response is the Basis of the Occurrence, Development and Resistance to Radioor Chemotherapy in Ovarian Cancer

Changsheng Peng

doi:10.34297/ajbsr.2020.11.001622

Abstract

Genome surveillance system is critical for eukaryotic cells to maintain genome stability [1,2]. Cell cycle checkpoints is quickly activated upon detecting various forms of DNA lesions, ensued by loading of repair factors to eliminate DNA damage [3]. ATM (Ataxia-Telangiectasia mutated) and ATR (ATM and Rad 3-related), the upstream checkpoint kinase, initiate damage detection and signal transduction after exposure to genotoxic insults including ionizing radiation or chemotherapeutic reagents [4].

Highlights

To Cite This Article: Changsheng Peng, Wei Zhang, The Activation of DNA Damage Response is the Basis of the Occurrence, Development and Resistance to Radio- or Chemotherapy in Ovarian Cancer. 2020 - 11(3)
To eliminate DNA lesions generated during genomic replication, ATR-dependent replication stress is activated to modulates the activities of the cell cycle regulator to halt cell cycle
Our study found that compared with normal ovarian cells, the genome monitoring system of ovarian cancer cells still plays a role

Summary

Introduction

The Activation of DNA Damage Response is the Basis of the Occurrence, Development and Resistance to Radioor Chemotherapy in Ovarian Cancer. *Corresponding author: Changsheng Peng, Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China. To Cite This Article: Changsheng Peng, Wei Zhang, The Activation of DNA Damage Response is the Basis of the Occurrence, Development and Resistance to Radio- or Chemotherapy in Ovarian Cancer.

Results

Conclusion