Abstract
Isolated uterine arteries from nonpregnant human uteri and pregnant sheep uteri responded in a similar manner to 7 vasopressor drugs. Epinephrine and norepinephrine were equal in vasoconstrictor activity and about 10 times more active than phenylephrine and metaraminol which were also equally active. Ephedrine, mephentermine, and dopamine produced contractions of uterine arteries but only at high concentrations. Neither halothane (0.45 to 0.50 per cent), nitrous oxide (70 per cent), nor lidocaine (3 μg per milliliter) altered contractions to epinephrine or norepinephrine.
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