Abstract
The venom used was an extract from the dried venom glands of the Sepedon hæmachates . Its minimum lethal dose by subcutaneous injection per kilogramme was found to be: for the frog, 0·0012 gramme; for the rabbit, 0·001 gramme; for the rat, 0·0016 gramme; for the car, 0·015 gramme; for the pigeon, 0·0033 gramme; and, by intravenous injection, for the rabbit, 0·00055 gramme. In the case of all these animals, the venom primarily and with greatest intensity affects the respiration. Respiratory paralysis is the cause of death in mammals and in birds; in frogs, the respiratory movements are early paralysed, but death occurs after several days from gradual failure of the circulation. Other conspicuous effects produced by lethal doses in mammals are drowsiness, ataxia, impairment of reflexes, and fall of temperature. In frogs, the venom produces diminution of reflex excitability, motor paralysis, and progressive increase in weight due to œdema.
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Schedule a callMore From: Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
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