Abstract
J. E. Dyr, J. Suttnar, J. Šimák, H. Fořtová and F. Kornalík. The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma. Toxicon 28, 1364–1367, 1990.—The action of a fibrin-promoting enzyme isolated from the venom of A. c. contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma.
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