Abstract
Copyright: © 2012 Duenas-Gonzalez A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cervical cancer is the third most commonly diagnosed cancer worldwide and the fourth leading cause of cancer death in females, accounting for 9% (529,800) of total new cancer cases and 8% (275,100) of total cancer deaths among females in 2008. This cancer mainly affects socially disadvantaged women; hence, it is much more common in developing countries, where 83% of cases occur [1]. Despite these figures, there is a shortage of novel therapeutical agents for invasive cervical cancer in late stages of development.
Highlights
These by no means suggest that efforts toward an effective personalized medicine using targeted agents should not be continued but “common-sense driven or educated guess” approach need not to be overlooked
The most compelling evidence on the key role of HPV oncoproteins in cervical cancer is the demonstration that repressing endogenous HPV oncogenes (E6/E7) mobilizes the p53 and Rb pathways in an orderly fashion to deliver growth inhibitory signals to the cells, unlike most cancers, in which the brakes on cell growth are broken, in HeLa cells -which are reminiscent of a advanced cervical cancer [11]- the driver is asleep, down-regulation of E6/E7 is sufficient to wake up the driver and impose growth control [12]
Cervical cancer is the third most commonly diagnosed cancer worldwide and the fourth leading cause of cancer death in females, accounting for 9% (529,800) of total new cancer cases and 8% (275,100) of total cancer deaths among females in 2008. This cancer mainly affects socially disadvantaged women; it is much more common in developing countries, where 83% of cases occur [1]
Summary
These by no means suggest that efforts toward an effective personalized medicine using targeted agents should not be continued but “common-sense driven or educated guess” approach need not to be overlooked.
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