Abstract
BackgroundThe -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis.MethodsWe searched Pubmed, Embase, CNKI and Wanfang databases, covering all studies until April 29th, 2011. Statistical analyses were performed using the Revman4.2 and STATA10.0 software.ResultsA total of 5341 cases and 6075 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the GG homozygote carriers had a 67% increased risk of TB compared with the A allele carriers (GG vs. GA+AA: OR = 1.67, 95%CI = 1.25–2.23, P = 0.0006). In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Latinos, but not in Africans (GG vs. GA+AA: OR = 1.79, 95%CI = 1.19–2.70 and P = 0.005 for Asians; OR = 2.15, 95%CI = 1.32–3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45–3.64 and P = 0.65 for Africans).ConclusionThis meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.
Highlights
Tuberculosis (TB) is still one of the main causes of death due to infectious diseases [1,2]
It is reported that one third of the population had ever been infected by Mycobacterium Tuberculosis(MTB), but only 10% of the infected population might develop to TB with clinical symptoms [4]
Two studies were excluded for not being relevant to TB risk and the monocyte chemoattractant protein-1 (MCP-1) gene
Summary
Tuberculosis (TB) is still one of the main causes of death due to infectious diseases [1,2]. It is reported that one third of the population had ever been infected by Mycobacterium Tuberculosis(MTB), but only 10% of the infected population might develop to TB with clinical symptoms [4]. Both the MTB and the host immune response may play important roles in the development of TB [5]. The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis
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