The 15-membered ring macrolide tulathromycin inhibits plasma endotoxin activity in endotoxemic calves

Abstract

Macrolide antibiotics have not only bacteriostatic effects, but also anti-inflammatory effects via the inhibition of cytokine release. The 15-membered ring macrolide tulathromycin is widely used for cattle with inflammatory pneumonia. However, its anti-inflammatory activity, especially against endotoxin, remains unclear. The purpose of this study was to investigate whether tulathromycin-containing plasma inhibited endotoxin (ETX) activity in vivo and in vitro.