Thalamo-cortical sensorimotor circuit in Multiple Sclerosis: an integrated structural and electrophysiological assessment

Abstract

Event Abstract Back to Event Thalamo-cortical sensorimotor circuit in Multiple Sclerosis: an integrated structural and electrophysiological assessment Doriana Landi1, Giancarlo Zito2, Filippo Zappasodi3, Domenico Lupoi4, Paolo M. Rossini1, Maria M. Filippi2 and Franca Tecchio5* 1 Università Campus Biomedico, Neurologia Clinica, Italy 2 Isola Tiberina, Dipartimento di Neuroscienze, AfaR, Italy 3 G. D Annunzio University, Department of Clinical Sciences and Bioimaging , Italy 4 Isola Tiberina, Unità Operativa Complessa Radiologia, AfaR, Italy 5 Isola Tiberina, CNR-ISTC, Unità MEG, Ospedale Fatebenefratelli, Italy Demyelination and axonal damage are pathologic hallmarks of Multiple Sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Relapsing Remitting MS patients without sensory symptoms at the time of the investigation. By magnetoencephalography (MEG), the recruitment pattern within the primary sensory (S1) and motor (M1) areas was estimated through the morphology of the early components of somatosensory evoked magnetic fields (SEFs), after evaluating the S1 responsiveness to sensory inputs from the contralateral arm. In each hemisphere, network recruitment properties were correlated with ispi-lateral thalamus volume, estimated by morphometric techniques upon high resolution 3D structural magnetic resonance (MR) images. S1 activation was preserved while SEF morphology was strikingly distorted in MS patients, marking a disruption of primary somatosensory network patterning. An unbalance of S1-M1 dynamic recruitment was documented, correlated with the thalamic volume reduction in the left hemisphere. These findings support the model of MS as a disconnection syndrome, with major susceptibility to damage experienced by nodes belonging to more frequently recruited and highly specialized networks. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG: Clinical applications Citation: Landi D, Zito G, Zappasodi F, Lupoi D, Rossini PM, Filippi MM and Tecchio F (2010). Thalamo-cortical sensorimotor circuit in Multiple Sclerosis: an integrated structural and electrophysiological assessment. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00293 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Apr 2010; Published Online: 05 Apr 2010. * Correspondence: Franca Tecchio, Isola Tiberina, CNR-ISTC, Unità MEG, Ospedale Fatebenefratelli, Rome, Italy, franca.tecchio@istc.cnr.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Doriana Landi Giancarlo Zito Filippo Zappasodi Domenico Lupoi Paolo M Rossini Maria M Filippi Franca Tecchio Google Doriana Landi Giancarlo Zito Filippo Zappasodi Domenico Lupoi Paolo M Rossini Maria M Filippi Franca Tecchio Google Scholar Doriana Landi Giancarlo Zito Filippo Zappasodi Domenico Lupoi Paolo M Rossini Maria M Filippi Franca Tecchio PubMed Doriana Landi Giancarlo Zito Filippo Zappasodi Domenico Lupoi Paolo M Rossini Maria M Filippi Franca Tecchio Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.