Abstract
Introduction: The prognostic value of transforming growth factor beta-1 (TGF-s1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis. Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively. Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival. Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation. Keywords : Head and neck neoplasms; prognosis; transforming growth factors
Highlights
The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear
TGF-β1 was significantly increased in oral squamous cell carcinoma (OSCC) compared to normal oral mucosa (
No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival
Summary
The aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity, and patients’ prognosis. The aim of the present study was to identify the role of TGF-β1 immunostaining as a prognostic marker of OSCC
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