Abstract
1,2-Dihydro-1 -arylnaphtho[1,2-e][1,3]oxazine-3-one derivatives were synthesized in high yields using an efficient and one-pot condensation of 2-naphthol, aromatic aldehydes and urea catalyzed by tetramethylammonium hydroxide (TMAH) under solvent-free conditions. KEY WORDS: TMAH, Naphthoxazine-3-one, Solvent-free reaction, 2-Naphthol, Multi-component reactions Bull. Chem. Soc. Ethiop. 2016, 30(1), 161-164.DOI: http://dx.doi.org/10.4314/bcse.v30i1.16
Highlights
Multi-component reactions (MCRs) have emerged as an efficient and powerful tool in modern synthetic organic chemistry
A new method for the synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones is the reaction between 2-naphthol, aromatic aldehydes and urea, but this reaction need to catalyst for promotion
In continuation of our pervious works on the applications of catalysts in the synthesis of heterocyclic compounds[15, 16], in this article, we present a one-pot, three-component method for the preparation of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-one derivatives in the presence of tetramethylammonium hydroxide (TMAH) at room temperature under solvent-free conditions (Scheme 1)
Summary
Multi-component reactions (MCRs) have emerged as an efficient and powerful tool in modern synthetic organic chemistry. A new method for the synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones is the reaction between 2-naphthol, aromatic aldehydes and urea, but this reaction need to catalyst for promotion. In continuation of our pervious works on the applications of catalysts in the synthesis of heterocyclic compounds[15, 16], in this article, we present a one-pot, three-component method for the preparation of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-one derivatives in the presence of tetramethylammonium hydroxide (TMAH) at room temperature under solvent-free conditions (Scheme 1).
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