Abstract
Arsenic (As) compounds are reported as environmental toxicants and human carcinogens. Exposure to arsenic imposes a big health issue worldwide. Tetrahydrocurcumin (THC) is an antioxidative substance, which is derived from curcumin, the component of turmeric. In view of this fact, the purpose of this study was to delineate the ameliorative role of THC against arsenic-induced hepatotoxicity in rats. In this context, we evaluated the mode of action of chronic oral exposure of sodium arsenite as the source of arsenic at 5 mg/kg/BW with THC (80 mg/ kg/BW) for 28 days. Hepatotoxicity was evaluated by the increased activities of serum hepatospecific enzymes namely aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma glutamyl transferase, lactate dehydrogenase and total bilirubin along with increased elevation of lipid peroxidative markers, thiobarbituric acid reactive substances, lipid hydroperoxides, protein carbonyl content and conjugated dienes. The toxic effect of arsenic was also indicated by significantly decreased activities of membrane bound ATPases, enzymatic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and glucose-6-phosphate dehydrogenase along with non-enzymatic antioxidants like reduced glutathione, total sulfhydryl groups, vitamins C and E. Administration of THC exhibited a significant reversal of arsenic-induced toxicity in hepatic tissue. All these changes were supported by reduction of histopathological observations of the liver. These results suggest that THC has a potential protective effect over arsenic-induced hepatotoxicity in rat.
Highlights
Arsenic is a naturally occurring metalloid found in the environment, coming under one of the heavy metal and human carcinogen [1]
A significant (p
These observations were related to our previous publication by Muthumani and Milton prabu [52] who reported that high Arsenic exposure have significantly induced disturbances of the intake of water and food, total body weight, absolute and relative liver weights of rats
Summary
Arsenic is a naturally occurring metalloid found in the environment, coming under one of the heavy metal and human carcinogen [1]. Bi-inorganic form of As in drinking water are trivalent (As+3) such as arsenic trioxide and sodium arsenite and pentavalent (As+5) such as arsenic pentoxide and the various arsenates. Drinking water is a major source of Arsenic in the environment to public health [4]. Other vehicles of As are agricultural applications such as insecticides, herbicides, fungicides, algaecides, sheep dips, wood preservatives and by-products of fossil fuels [5]. As compounds are used in the manufacture of the products like glass, semiconductors, dyestuffs, smelters, cotton gins, cigarette and as an additive to metal alloys [6]
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