Abstract
Rotational behaviour (turning) was induced in morphine-dependent rats during precipitated abstinence after acute pretreatment with Δ 8- or Δ 9-tetrahydrocannabinol. This tetrahydro-cannabinol-stimulated turning varied with degree of morphine dependence and was blocked by haloperidol, but not promethazine. Significant attenuation of naloxone-induced abstinence signs was also observed after acute tetrahydrocannabinol pretreatment, but only in highly (72 hr) morphine-dependent rats. The combination of tetrahydrocannabinol and haloperidol pretreatment was more effective in attenuating abstinence than was either haloperidol or tetrahydrocannabinol pretreatment alone. These data provide additional evidence for the alteration of CNS dopaminergic function in morphine dependence.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
