Abstract
Solid supported bilayer lipid membranes are model systems to mimic natural cell membranes in order to understand structural and functional properties of such systems. The use of a model system allows for the use of a wide variety of analytical tools including atomic force microscopy, impedance spectroscopy, neutron reflectometry, and surface plasmon resonance spectroscopy. Among the large number of different types of model membranes polymer-supported and tethered lipid bilayers have been shown to be versatile and useful systems. Both systems consist of a lipid bilayer, which is de-coupled from an underlying support by a spacer cushion. Both systems will be reviewed, with an emphasis on the effect that the spacer moiety has on the bilayer properties.
Highlights
Biological membranes and membrane related processes are essential for every living organism.They form the outer layer of cells and organelles and host a large variety of proteins that are essential to the functioning of every cell
Most novel pharmaceuticals target G-protein coupled receptors [7], which makes this class of membrane proteins the most important drug target ever discovered [8]
The cell membrane serves as the outermost barrier of the cell against pathogens
Summary
Biological membranes and membrane related processes are essential for every living organism. As an extension of sBLMs, polymer supported and tethered lipid bilayer membranes have been developed These model systems separate the lipid bilayer from the substrate by a spacer moiety. Polymer supported bilayersinto were used to in it was that theinrod-shaped complex is embedded thealso lipid bilayer successfully incorporate a range of proteins in a functional form, for example, Adenylate. They have been used to monitor the binding between Human Platelet Integrin and liganda range of proteins in a functional form, for example, Adenylate Cyclase [30] They have been containing vesicles with high efficiency, demonstrating that little to no loss of functionality occurred used to monitor the binding between Human Platelet Integrin and ligand-containing vesicles with once the protein was incorporated into a polymer-supported membrane [31]. High efficiency, demonstrating that little to no loss of functionality occurred once the protein was incorporated a polymer-supported membrane [31]
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