Abstract
1. 1. Tetanus-induced (400 Hz, 200 pulses) long-lasting potentiation of the stratum radiatumevoked CA 1 population spike in hippocampal slices is not accompanied by any change in Na +-independent [ 3H]glutamate binding sites. 2. 2. Homosynaptic depression that occurs subsequent to either a low frequency tetanus (20 Hz, 600 pulses) or a transient exposure to Cl −-free (containing NO − 3) medium is associated with an elevation in the amino acid binding. 3. 3. [ 3H]Glutamate uptake into slices was decreased following a high frequency (400 Hz, 200 pulses) tetanus but in the majority of cases was increased following a low frequency (20 Hz, 600 pulses) tetanus to stratum radiatum. 4. 4. When the high frequency tetanus was given in the absence of extracellular Ca 2+, there was a further reduction in [ 3H]glutamate uptake.
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