Abstract
Indices of performance were derived for the two approaches by a simulation study implementing different ground-truth networks under different levels of signal-to-noise ratio and amount of data available for the estimate. The two approaches were then applied to the resting-state EEG data acquired in a group of minimally conscious state and vegetative state/unresponsive wakefulness syndrome patients. The performances of the asymptotic statistics in simulations matched those obtained by the empirical approach, with a considerable reduction of the computational time. Results of the application to real data showed that the asymptotic statistics led to the extraction of connectivity-based indices able to discriminate patients in different disorders of consciousness conditions and to correlate significantly with clinical scales. Such results were similar to those obtained by the empirical assessment, but with a considerable time economy. Asymptotic statistics provide an approach to the assessment of PDC significance with comparable performances with respect to the previously used empirical approaches but with a substantial advantage in terms of computational time.
Published Version
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