Abstract
ABSTRACT This study investigates the thermodynamic characteristics, equilibrium solubility, and solvation dynamics of sildenafil citrate within binary solvent systems composed of propylene glycol and 1-propanol. Utilizing both determination and computational approaches, the solubility patterns of sildenafil citrate were quantitatively assessed, revealing direct proportionality with increments in temperature and the concentration of propylene glycol. A comparative analysis using three distinct mathematical models to represent the solid–liquid phase equilibrium was conducted. Among these, the Jouyban-Acree-van’t Hoff model yielded the most comprehensive correlation by covering the effects of both temperature and solvent composition variations on the solubility, with a mean relative deviation (MRD%) of 6.4%, suggesting a robust alignment between the modelled and experimental solubility data. Previously trained models were tested to predict the solubility of the drug in mono- and mixed-solvents at various temperatures where accurate predictions were obtained with the MRD% of 19.1% (for mono-solvents), 8.1 and 14.4% (for mixed solvent systems).
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