Abstract
We have elaborated new test systems for rapid in vitro and in vivo estimation of the risk and prediction of the development of delayed neurotoxicity (DNT) caused by organophosphorus (OP) compounds. The test is based on rapid estimation of the DNT potential of an OP compound with respect to its ability to inhibit the activity of neurotoxic esterase in blood lymphocytes. The proposed system can be used for the early diagnostics of DNT in humans upon acute poisoning with OP compounds.
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