Abstract
It has been shown numerically (Millonas and Chialvo 1996 Phys. Rev. Lett. 76 550) that voltage-gated ion channels can be focused into specific conformational states by the application of fluctuating voltages, such as dichotomous noise. We present results of an experimental test performed on Shaker K+ channels. We applied dichotomous noise with properties mimicking the numerical simulations as closely as physiologically feasible. We observed that the probability for intermediate states can be increased as much as 50% above the maximal value for any static voltages.
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