Abstract
The essential roles of protein–protein interaction in sigma-1 receptor functions
Highlights
Dopamine D1 receptors (Monnet et al, 1990; Navarro et al, 2010)
It is yet to be determined whether σ-1R modulates the N-methyl-D-aspartate receptors (NMDARs) function through protein– protein interactions
It is unclear at the moment if the σ-1R associates with ion channels at the endoplasmic reticulum (ER)/mitochondrial associated membranes (MAM), and after association, whether or not the entire complex (σ-1R-ion channel) is translocated to the plasma membrane
Summary
Dopamine D1 receptors (a GPCR) (Monnet et al, 1990; Navarro et al, 2010). The σ-1R modulation of D1R is through protein–protein interactions (Navarro et al, 2010). It is still unknown if there is any physical association between SK channels and σ-1Rs. How does the σ-1R, being an intracellular protein, modulate the functions of numerous cellular components that are present at the plasma membrane?
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