Test and clinical significance of immunoglobulin and complements in hand foot and mouth disease combined with acute flaccid paralysis

Abstract

Objective To study the serum immunoglobulin IgG, IgM, IgA and complements C3, C4 level changes in hand foot and mouth disease(HFMD) combined with acute flaccid paralysis(AFP). Methods The cases were divided into three groups in this study, including 30 cases of HFMD, 30 cases of HFMD combined with AFP, and 30 cases of healthy(normal control group). Immunoturbidimetric assay was used to test the level changes of IgG, IgM, IgA, and complements C3, C4. Results The IgG, IgA, C3 and C4 in HFMD combined with AFP group were (5.49±1.04) g/L, (0.39±0.27) g/L, (0.65.±0.19) g/L and (0.16.±0.11) g/L respectively, lower than those in HFMD group((7.07±1.63) g/L, (0.55±0.32) g/L, (0.97.±0.18) g/L, (0.23.±0.09) g/L) and normal control group((9.58±1.42) g/L, (0.81±0.33) g/L, (1.28.±0.25) g/L, (0.34.±0.16) g/L), there were statistically significant differences among groups(F=12.04, 1.84, 1.65, 1.29; P=0.031, 0.020, 0.018, 0.025). However, the expression of IgM in HFMD combined with AFP group was (1.34±0.26) g/L, higher than that in HFMD group((1.02±0.29) g/L) and normal control group((0.76±0.28) g/L), the difference was statistically significant(F=3.62, P=0.014). Conclusion HFMD combined with AFP exists severe humoral immune dysfunction, which provides a theoretical evidence for the prevention and treatment of HFMD combined with AFP. Key words: Hand foot and mouth disease; Acute flaccid paralysis; Immunoglobin; Complements