Test Activity Combinations of Celery Herb (<i>Apium graveolens</i> L.) and Bay Leaf (<i>Syzygium polyanthum</i> W.) Ethanol Extract Toward DecreasedLipid Profile Levels in Hypertensive Mice

Abstract

Celery herb contains flavonoid which can hamper cholesterol synthesis through inhibitor HMG-CoA reductase. Bay leaf has a working mechanism that stimulates bile fluid secretion and stimulates blood circulation. This research aims to know the activity combinations of bay leaf ethanol extract (BLEE) and celery herb ethanol extract (CHEE) and to know which dose mostly can decrease lipid profile levels. The design of this research uses experimental withpre-post control group design.The mice are rendered with NaCl 8% solution and High Fat Feed. The mice are divided into 9 groups, in each group there are 5 mice which are normal group, control group, HCT group, Simvastatin group, and CHEE 4.50 mg/kgBW, BLEE 25.00 mg/kgBW, combination 1, combination 2, and combination 3. Data analysis is conducted with Normality test,One Way ANOVAtest,Kruskal-Wallis,Mann-Whitney. Based on the research after they are induced with NaCl 8% solvent and given high-fat feed, the extract can increase total cholesterol levels, triglycerides, LDL, and also significantly decrease HDL (p <0.05). After giving a test extract solution, it can reduce total cholesterol, triglycerides, LDL, and also significantly increase HDL levels (p <0.05). The conclusion, the three variations combinations dose can decrease total cholesterol, Triglycerides, LDL, and also increase HDL levels, and combination dose 3 has the greatest decrease in total cholesterol, triglyceride, LDL, and the highest increase in HDL levels. So the lower the total cholesterol level, the lower the possibility of hypertension.