Abstract
Successful production of 1:1 sulfamethazine-acetylsalicylic acid (SMZ-ASA) cocrystal was achieved through slow solvent evaporation, liquid-assisted grinding, and slurry conversion method. SCXRD, PXRD, DSC, FTIR, and Raman spectroscopy were employed to characterize the cocrystal. Ternary phase diagrams (TPD) for SMZ and ASA in acetonitrile (ACN) and deionized water (DIW) has been constructed at 25 ℃. Using TPD of the incongruent system, slurry compositions for stable production of cocrystal was determined in both the solvents. The cocrystal conversion process in slurry was monitored using in-situ Raman spectroscopy. Intermittent sampling was also carried out to determine the purity of the solid phase from the slurry using offline PXRD. In-situ Raman and offline PXRD measurements confirmed fast conversion of the pure coformer crystals to the cocrystal in ACN, within a span of 5 minutes. However, the conversion in DIW was much slower and the in-situ Raman measurements significantly underpredicted the transformation time in comparison to offline PXRD analysis. The study highlights the utilization of TPD for developing the cocrystallization process and the need for multiple characterization techniques for monitoring cocrystallization.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Similar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.