Abstract
Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund's Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund's Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.
Highlights
Every organism eliminates foreign invaders such as infectious pathogens or damaged tissues by a complex host response known as inflammation
Chronic inflammation leads to various pathological conditions like atherosclerosis, metabolic syndromes, arthritis, allergies, cancer, and various other autoimmune diseases
General treatment relies on the use of steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) which exhibit several adverse effects [2]
Summary
Every organism eliminates foreign invaders such as infectious pathogens or damaged tissues by a complex host response known as inflammation. Inflammation is a protective response intended to eliminate the cause of cell injury. Acute inflammation is a rapid response to injuries, microbes, or other foreign substances. Chronic inflammation is a prolonged duration of inflammation in which active inflammation and tissue injuries proceed simultaneously [1]. Chronic inflammation leads to various pathological conditions like atherosclerosis, metabolic syndromes, arthritis, allergies, cancer, and various other autoimmune diseases. Apart from NSAIDs, there are some alternative treatments available for inflammation and autoimmune diseases. Monoclonal antibodies (mAbs) are one of the treatment options giving a positive hope in the management of chronic inflammatory-related diseases. Adalimumab (trade name: Humira) is one of the human monoclonal antibodies currently available for the treatment of autoimmune diseases
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
