Abstract
Cells from patients with acute lymphoblastic leukemias (ALL) (28 cases), T-derived chronic lymphocytic leukemias (CLL) (6 cases), Sezary syndrome (3 cases) and thymomas (3 cases) were studied for both immunological membrane phenotype and terminal deoxynucleotidyl transferase (TdT) content (using chromatography of cell extracts on phosphocellulose). Cells from 25 cases of ALL contained TdT. T-derived ALL had relatively homogenous TdT values whereas a wider range of TdT activity was found in non-T non-B ALL. Cells from 3 ALL cases had no detectable enzyme; two were B-derived ALL, one T-derived ALL. Cells from the three thymomas and from one case each of Sezary syndrome and T-CLL had TdT activity. The significance of TdT in neoplastic disorders is discussed in the light of the known distribution of TdT in various subpopulations of normal mature T-cells and T-cell precursors.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call