Teratogenic effects of vitamin A on embryos of pregnant rats

Abstract

Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, thirty female Albino Rats are used. The present study has been intended to show the teratogenic effects of Vitamin A on embryos in female Albino Rats. The females Rats are randomly divided into four main groups,The first and second control groups are given orally injection of physiological normal saline and the third group 15th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for fifteen days from the first day to the end of experimental allocated for each female. The fouth group 20 th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for tewnty days from the first day to the end of experimental allocated for each female. The rats are sacrificed in 15,20 th (dpc) to study the teratogenic effects on embryonic bodies.Retinol doses ten, twenty μcg/kg/day caused macroscopic malformations in embryos of female rats compare to control group.In conclusion; Vitamin A caused malformations of embryos in 15 th and 20 th (dpc).