Tensile strengths of paracetamol and Avicel powders and their mixtures.

Abstract

Measurements were made of the tensile strengths of paracetamol and Avicel powders and of their mixtures. Two quantities were derived from the results; m, a universal constant whose value was 1.00 +/- 0.23 and alpha, a constant of the material. The value of alpha for paracetamol was much larger than that for Avicel and increased slightly with increase in particle size. Adding 25% w/w of Avicel to paracetamol produced a significant decrease in alpha and this fact may account for its use as an excipient in the tableting of paracetamol.