Abstract

The large effects of minimal structural variations are demonstrated by enediynes 1. At 50 °C the cis isomer cyclizes much faster (t1/2 = 4 h) than the trans isomer (t1/2 = 22 h). The carbonate derivative of trans-l is stable even for several hours at 100 °C. The exploration of the chemistry of cyclic enediynes is prompted by their DNA-cleaving properties.

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