Abstract
Most focal seizures originate in the temporal lobe and are commonly divided into mesial and lateral temporal epilepsy, depending upon the neuronal circuitry involved. The hallmark features of the mesial temporal epilepsy are aura, unconsciousness, and automatisms. Symptoms often overlap with the lateral temporal epilepsy. However, the latter present a less evident psychomotor arrest, frequent clones and dystonic postures, and common focal to bilateral tonic–clonic seizures. Sclerosis of the hippocampus is the most frequent cause of temporal lobe epilepsy (TLE). TLE is among all epilepsies the most frequently associated with psychiatric comorbidity. Anxiety, depression, and interictal dysphoria are recurrent psychiatric disorders in pediatric patients with TLE. In addition, these alterations are often combined with cognitive, learning, and behavioral impairment. These comorbidities occur more frequently in TLE with hippocampal sclerosis and with pharmacoresistance. According to the bidirectional hypothesis, the close relationship between TLE and psychiatric features should lead to considering common pathophysiology underlying these disorders. Psychiatric comorbidities considerably reduce the quality of life of these children and their families. Thus, early detection and appropriate management and therapeutic strategies could improve the prognosis of these patients. The aim of this review is to analyze TLE correlation with psychiatric disorders and its underlying conditions.
Highlights
Temporal lobe epilepsy (TLE) is the most common focal epilepsy [1]
Dystonic posturing seems to be associated with basal ganglia involvement, whereas oral automatisms seem to be related to amygdala activation [1, 5,6,7,8,9]
Ictal-electroencephalography (EEG) in mesial temporal lobe epilepsy (mTLE) is characterized by focal rhythmic activity in the theta range (5– 9 Hz) with maximum amplitude in the basal temporal electrodes, preceded or not by bilateral hypersynchronous slowdown. neocortical temporal lobe epilepsy (nTLE) might have a wider distribution at seizure onset with the typical presence of polymorphic activity at 2–5 Hz in inferiortemporal regions
Summary
Valerio Vinti 1, Giovanni Battista Dell’Isola 1*, Giorgia Tascini 1, Elisabetta Mencaroni 1, Giuseppe Di Cara 1, Pasquale Striano 2,3 and Alberto Verrotti 1. Symptoms often overlap with the lateral temporal epilepsy. The latter present a less evident psychomotor arrest, frequent clones and dystonic postures, and common focal to bilateral tonic–clonic seizures. Sclerosis of the hippocampus is the most frequent cause of temporal lobe epilepsy (TLE). TLE is among all epilepsies the most frequently associated with psychiatric comorbidity. Depression, and interictal dysphoria are recurrent psychiatric disorders in pediatric patients with TLE. These alterations are often combined with cognitive, learning, and behavioral impairment. These comorbidities occur more frequently in TLE with hippocampal sclerosis and with pharmacoresistance.
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