Abstract
Method 23 patients with STEMI undergoing primary PCI were prospectively enrolled and sequential CMR imaging was performed within 96 hours of admission and at 1 month follow up. LV volumetric quantification was performed (QMass MR, Medis, Leiden, The Netherlands) with manual planimetry of the endocardial contours in all temporal phases of the contiguous short-axis slices. Systolic parameters were obtained. Diastolic CMR parameters were derived including peak filling rate (PFR) and its index normalized to end diastolic volume (NPFR), time to peak filling rate (TPFR), diastolic volume recovery (DVR80): proportion of diastole required for recovery of 80 percentage of stroke volume as well as the ratio of the biphasic early (E) and late (A) filling profiles (E/A ratio). The change in those parameters was then correlated to peak troponin-I and baseline LVEF.
Highlights
Diastolic dysfunction is one of the earliest manifestations of cardiac ischemia
We aim to evaluate changes in diastolic function after ST elevation myocardial infarction (STEMI) using volumetric cardiac magnetic resonance imaging (CMR), as well as the relation of diastolic parameters to baseline variables including peak troponin-I and baseline left ventricular ejection fraction (LVEF)
There were no significant changes in LV volumes; LV end diastolic volume changed from 194.5ml ( 152.9-237.0) to 192ml (152.5-221.7), p=0.14) and LV end systolic volume from 100ml (65.0-125.8) to 87.71ml (52.8-96.0), p=0.08
Summary
Gopal Ghimire*, Jyotshana Shrestha, Manuel A Gonzalez, Ana Barac, Rebecca Torguson, William O Suddath, Lowell F Satler, Augusto D Pichard, Ron Waksman, Anthon R Fuisz, Gaby Weissman. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
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