Abstract
N.V. Timofeev-Ressovsky made a decisive contribution to the template principle, offered by his teacher, N.K. Koltsov . Idea of “covariant reduplication” of Timofeev-Ressovsky embraced inheritance and variation in terms of replication of genetic material as a template process. Later on F.Crick included in the template principle processes of genes expression through transcription and translation in his Central Dogma of Molecular Biology . Replication, transcription, translation as the first order template processes (TP I) operating with their universal characteristics (ambiguity and repair , or correction ) should be considered along with the second order template processes (TP II), operating with spatial, or conformational templates . The attention to the former ones had been stimulated at the end of XX century by the study of prions and amyloids . Comparative characteristics of the TP I and TP II and of their interaction are discussed.
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