Abstract
Despite the advantages proffered by technology in science education, little has been done to develop and validate innovative technology-based instructional materials on Central Dogma of Molecular Biology. It is imperative to test any newly generated instructional materials to validate their quality before being widely used. Hence, this study aimed to validate the developed simulation-based instructional materials on Central Dogma of Molecular Biology for Senior High School. This study utilized Research and Development (RD) design involving 50 Grade 12 STEM learners and 15 Biology education experts chosen through purposive sampling. Results revealed that experts strongly agreed that the developed simulation-based instructional materials on Central Dogma of Molecular Biology have content, technical, and instructional qualities. Meanwhile, the pretest and posttest results revealed that the learners demonstrated significant conceptual improvement from approaching proficiency to advanced mastery level in Central Dogma of Molecular Biology concepts. Further, the learners' pretest and posttest mean scores on the concepts differed significantly (p0.05). Therefore, it is recommended that the developed simulation-based instructional materials be used to complement in teaching Central Dogma of Molecular Biology.
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