Temperature increases associated with polymerization of irradiated PAG dosimeters

Abstract

Polyacrylamide gel (PAG) dosimeters show considerable promise as three-dimensional dosimeters for the verification of complex dose distributions associated with conformal therapy. However, the potential of PAG dosimeters has not yet been borne out in clinical practice and it is apparent that basic investigations of these dosimeters are still required.The polymerization reactions in PAG dosimeters are exothermic and the heat given off by the reactions may influence polymerization reaction kinetics. We report the results of in situ measurements of local temperature increases in irradiated PAG resulting from heat generated by the radiation-induced exothermic polymerization reactions. Temperature changes proportional to the absorbed dose were observed in the irradiated gels, reaching a maximum of 12 °C under high-dose conditions, depending on the thermal boundary conditions. This has practical implications, for example, using small vials of PAG to calibrate large phantoms may not be appropriate since temperature differences during irradiation between the calibration vials and phantom may alter the morphology and quantity of the polymer formed, even when irradiated to the same dose. The inhibition of radiation-induced polymerization associated with low-level oxygen contamination is manifested by a delay in the onset of temperature rise during irradiation. The observed temperature changes are used to estimate the percentage conversion of double bonds from the bis/acrylamide monomers by polymerization reactions.