Abstract
Children born in the fall are at increased risk for developing atopic dermatitis (AD) and food allergy (FA), two conditions associated with skin barrier dysfunction. During an analysis of meteorological data in Denver, we found that the most extreme 24-hour temperature fluctuations occur in the fall. This prompted us to evaluate the effect of temperature on epidermal differentiation and Ca2+ transport function of transient receptor potential vanilloid (TRPV) ion channels involved in skin temperature sensing.
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