Abstract
Telomere biology in the Drosophila germline: link between chromatin structure, transcription and nuclear localization
Highlights
Supported by the project „BIOCEV” (CZ.1.05/1.1.00/02.0109) and “Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging” (No CZ.02.1.01/0.0/0.0/16_013/0001 775) funded by the European Regional Development Fund, by GACR (16-03403S and 18-19714S) and UMG/RVO: 68378050
We study the SUN/ KASH complex, which is important in the process of chromosome pairing at early stages of meiosis I
We discovered that some dedicated mutations in conserved lamin protein (CeLMN) gene affect dynamics of SUN/KASH complex
Summary
Supported by the project „BIOCEV” (CZ.1.05/1.1.00/02.0109) and “Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging” (No CZ.02.1.01/0.0/0.0/16_013/0001 775) funded by the European Regional Development Fund, by GACR (16-03403S and 18-19714S) and UMG/RVO: 68378050. Of Epigenetics of the Cell Nucleus, Vestec, Czech Republic; 2 Institute of Molecular Genetics ASCR, v.v.i., Lab. of Biology of the Cell Nucleus, Prague, Czech Republic lenka.hulkova@img.cas.cz Lamins are organized at the nuclear periphery, where form the main component of nuclear lamina and participate in many roles, such as maintenance of nuclear shape, regulation of gene expression, transcription, DNA replication, segregation of chromosome, meiosis and apoptosis. Our project focuses on the molecular mechanisms and regulation of chromosomal dynamics during gametogenesis.
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