Abstract
Objectives: Development of antimicrobial resistance in microorganism isolated from blood stream infection constitutes a major concern about their treatment. Teicoplanin is a glycopeptide antibiotic used in the treatment of infection caused by Gram-positive bacteria. This study was planned to determine Teicoplanin resistance in the Central India and recommend policy changes for prevention of the future resistance to the higher antibiotics. Methods: A total of 1855 septicemia suspected blood samples were studied. The blood culture samples were processed and identified in the microbiology laboratory according to the Clinical and Laboratory Standards Institute guidelines. Antibiotic susceptibility test was done using Kirby B disk diffusion method. Results: About 39.5% of blood culture samples showed positive growth for organism. We observed high teicoplanin resistance (29.5%) among Gram-positive isolates, predominantly (53%) in the Enterococcus species. Conclusion: Teicoplanin resistance has emerged tremendously in the present study. Hence, attention is required about this serious issue otherwise very limited choice of antibiotics will be available for treating infections in the future.
Highlights
Teicoplanin is a glycopeptide antimicrobial agent which has almost similar antimicrobial spectrum as Vancomycin. It is active against infections caused by Coagulase Negative Staphylococcus (CONS), various Enterococcus species, Methicillin-Resistant Staphylococcus Aureus, and in some cases Vancomycin Resistance Staphylococci [1]
Antibacterial activity of Teicoplanin is affected by its protein binding capacity, it is highly bound by plasma proteins (90–95%)
Resistance to teicoplanin (Table 4) The resistance to Teicoplanin among different Gram-positive bacterial isolates was found to be in staphylococcus 20 (23%), CONS 8 (40%), and Enterococcus 8 (53%)
Summary
Teicoplanin is a glycopeptide antimicrobial agent which has almost similar antimicrobial spectrum as Vancomycin. It is active against infections caused by Coagulase Negative Staphylococcus (CONS), various Enterococcus species, Methicillin-Resistant Staphylococcus Aureus, and in some cases Vancomycin Resistance Staphylococci [1]. It is a bactericidal agent against susceptible Gram-positive bacterial strains and may be effective in Clostridium difficile-associated diarrhea and pseudomembraneous colitis. Major and minor components contain a third carbohydrate moiety-Beta-D-glucosamine, all share same core of glycopeptides termed as teicoplanin A3-1 [4]. Teicoplanin has a long serum elimination half-life, (up to 100 h) with normal renal function in adult patients [5]
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