Abstract
In the pharmaceutical market of Ukraine, liquid dosage forms of hawthorn are present and used in complex treatment of cardiovascular diseases. Ukrainian flora has more than 30 species of hawthorns, among which there are unofficial species of wild and cultural species with sufficient raw material base.Aim. To develop a technology for obtaining of dense fruit extracts of unofficial hawthorn species and to determine the chemical composition of the obtained extracts.Methods. For determination of BAS dense of hawthorn fruit extracts was used spectrophotometric method and the method of high performance liquid chromatography (HPLC).Results. The technological scheme of obtaining dense extracts of hawthorn fruit was developed. The content of amino acids, flavonoids and hydroxycinnamic acids was established in густих extracts of fruits C. prunifolia Sarg., С. pseudokyrtostilla Klok. and С. leiomonogyna Klok.. The content of flavonoids ranged from 4.27 % ±0.01 to 10.94 % ± 0.10; hydroxycinnamic acids - from 1.45 % ± 0.02 to 2.56 % ± 0.10. By used the HPLC method in all extracts was detected rutin, chlorogenic and ferulic acids. In dense extract of C. prunifolia Sarg. fruits apigenin-7-O-rhamnoside was identified; С. pseudokyrtostilla Klok. and С. leiomonogyna Klok. - apigenin-7-O-glycoside, apigenin, luteolin; С. leiomonogyna Klok.- luteolin-7-O-diglycoside and quercetin.Conclusions. Dense fruit extracts of C. prunifolia Sarg., С. pseudokyrtostilla Klok. and С. leiomonogyna Klok. were obtained. For the first time, the HPLC method in extracts has determined the content of flavonoids and hydroxycinnamic acids. A comparative study of the amino acid composition of the extracts was carried out
Highlights
Genus Hawthorn (Crataegus L.) is one of the polymorphous genus of the Rosaceae L. family and its representatives are widespread in Ukraine and in the world's flora
Having analyzed the raw material base and the degree of study of Ukrainian flora hawthorns, we concluded that attention should be paid to informal wild and cultural species, as promising sources of biologically active substances (BAS)
In order to prevent the destruction of BAС and to prevent the use of large volumes of 70 % ethanol R in the development of the technology for obtaining extracts, we offer a percolation method that does not provide for the heating of raw materials
Summary
Diabetes mellitus (DM) is one of the most common diseases with a steady tendency to increase, "a non-infectious epidemic of the 21st century" [1]. It is projected that by 2030 the number of patients will reach 552 million (9.9 % or 1 diabetes patient in 10 healthy adults), and by 2035 – to 592 million (10.1 %) [2]. The risk of stroke, in patients with diabetes, is 3–4 times higher. In 10 % of cases, vascular complications in patients with DM, lead to lethal effects [3]. The authors of numerous scientific papers in experimental and clinical studies have identified the leading role of oxygen and nitrogen radicals in the pathogenesis of diabetes and its complications, in particular, diabetic encephalopathy [4, 5]
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