Abstract
The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-one healthy participants were recruited, the facial skin characteristics of each donor were investigated, their skin bacterial DNA was isolated and metagenomic analysis was performed. The donors were divided into two groups for age and sex each to analyze their skin microbiomes. Moreover, we investigated the correlation between the skin microbiome and clinical characteristics. The alpha diversity of the skin microbiome was significantly higher in the elderly, and beta diversity was significantly different according to age. The comparative skin microbials showed that the genus Lawsonella was more abundant in the younger age group, and Enhydrobacter was predominant in the older age group. Staphylococcus and Corynebacterium were more abundant in males, while Lactobacillus was more abundant in females. Lawsonella had a negative correlation with skin moisture and brown spots. Staphylococcus and Corynebacterium both had negative correlations with the number of UV spots and positive correlations with transepidermal water loss (TEWL). Furthermore, Staphylococcus aureus had a negative correlation with skin moisture parameters.
Highlights
The interest in skin microbiome differences by ethnicity, age, and gender is increasing
The skin moisture content and skin tone were significantly higher in the female group; the number of UV spots and brown spots were higher in women
This study aimed to profile the distribution of facial skin microbiota according to age and gender in healthy Koreans and to confirm their association with skin characteristics
Summary
The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Paolo et al suggested that understanding the physiological changes in the skin according to gender can help derive cosmetic improvement methods to prevent skin a ging[14]. We focused on the facial skin microbiome of Koreans to investigate the differences by age and gender. Taxonomic differences in skin microbiota were compared and analyzed between the younger and older age groups and between male and female groups. Comparing and analyzing the skin microbiome and clinical information of healthy individuals was intended to lay a foundation for product development utilizing the skin microbiome
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