Abstract
10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group. Compound 2 was found to possess comparable antitumor activity with respect to taxol. This confirms that the functional group at C-10 in taxols is not involved in receptor binding
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