Abstract
Taurine is the most abundant free amino acid in heart. It has various effects on cardiac function, including improved cardiac performance in congestive heart failure1 and regulation of calcium homeostasis2. Because taurine prevents calcium overload in several heart failure models, it was felt that it might improve cardiac function in hearts subjected to a low sodium, high calcium medium. It is known that a remarkable decrease in extracellular sodium concentration leads to contracture3. Thus, in this study we examined the effect of taurine on changes in intracellular calcium concentration and tissue high energy phosphate content of perfused chick heart exposed to buffer containing a low sodium and high calcium concentration.KeywordsCalcium OverloadTyrode SolutionChick HeartDevelop TensionTaurine TreatmentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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