Tau, phospho-tau and S-100B protein in cerebrospinal fluid of children with multiple sclerosis

Abstract

Objective: Axonal injury and glial activation are now recognized as an early and most likely irreversible neuropathological process in Multiple Sclerosis (MS) demanding that immunomodulatory treatment should be instituted early. To investigate if surrogate markers of axonal injury and glia activation are elevated in the cerebrospinal fluid of children and adolescents with MS, we studied subjects with relapsing-remitting type of MS for the presence of tau-, phospho-tau- and S-100B protein.