Abstract
The purpose of this study was to mask the bitter taste of nizatidine (NZD) using cation-exchange resins. Amberlite IRP-69 and Dowex-50 containing cross-linked polystyrene backbones were used. The drug resin complexes were prepared by batch process using drug: resin ratios of 1:1, 1:3, and 1:5. The optimum drug: resin ratio and the time required for maximum percentage drug loading into the complexes were determined. The selected drug-resin complexes were evaluated for morphology, drug release, and taste. The NZD-Dowex complex was obtained at a drug: resin ratio of 1:5 using a stirring time of 1 h in order to get 100% loading of NZD. The NZD-Dowex complex had a spherical shape and smooth texture similar to Dowex resin. The NZD-Dowex complex with a ratio of 1:5 showed that in vitro drug release of 4.27% at 5 min in simulated salivary fluid of pH 6.8 and 99.67% at 1 h in simulated gastric fluid of pH 1.2. NZD’s bitter taste was effectively masked when it formed a complex with Dowex at a ratio of 1:5. This was proved by an electronic tongue and human test panel.
Highlights
The oral administration of several important pharmaceutical formulations is often hampered by their unpleasant bitter taste, especially for children and elderly patients, leading to noncompliance and hindering therapeutic management
We suggest that the NZD-Dowex complexes should be administered as a sachet and taken within 1 h before eating or drinking anything that may cause the change in gastric pH which can influence the bioavailability of NZD
The results indicate that the NZD-Dowex complex at a 1:5 ratio can suppress the drug release more efficiently than the NZD-Dowex complex at a 1:3 ratio at salivary pH, suppressing the bitter taste at the time of administration until it is swallowed and transferred to the stomach
Summary
The oral administration of several important pharmaceutical formulations is often hampered by their unpleasant bitter taste, especially for children and elderly patients, leading to noncompliance and hindering therapeutic management. The strong anion and Dowex 50 contain sulfuric acid sites whereas weak cation exchangers The selection of IER for taste masking applications properties of the IER and the nature of drug and site of drug delivery [7] Both weak and strong cation is primarily governed by the functional group properties of the IER and the nature of drug and site of and anion resins are being used to mask the bitter taste of drugs. Some ion IERs used extensively for drug delivery [7] Both weak and strong cation and anion resins are being used to mask the bitter taste taste and flavor-masking in industries are Amberlite IRP-64, Amberlite IRP-69, Indion 204, Indion of drugs.
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