Abstract
Purpose: Placenta-derived Mesenchymal stromal cells (PMSCs) have been widely explored for tissue engineering applications and have demonstrated high proliferation and capacity for chondrogenic differentiation in vitro. However, rapid induction of PMSC chondrogenic differentiation during therapeutic transplantation remains extremely challenging. Our previous studies discovered that transcription factor Twist1 plays a crucial role in stem cell maintenance, proliferation and lineage commitment. Particularly, gene silencing Twist1 increased formation of chondrogenic nodules and expression of chondrogenic markers in micromass culture of murine limb bud mesenchymal cells [1].
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