Abstract
An interesting route of administration for liposomes is the subcutaneous (s.c.) route of administration. Liposomes administered in this way can improve drug delivery to regional lymph nodes. The aim of the present study was to address biopharmaceutical factors related to the use of s.c. administered liposomes as a lymphotropic delivery system. Important factors influencing lymphatic disposition of s.c. administered liposomes were found to be the anatomical site of injection, liposome size, and the presence of phosphatidylserine (PS) in the liposomal bilayer. Other factors, such as lipid dose and the presence of a hydrophilic poly(ethyleneglycol) (PEG)-coating, had a negligible or only a slight effect on the lymphatic disposition of s.c. administered liposomes.
Published Version
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